A Major Genotype in UDP-glucuronosyltransferase 2B15

Kenji TOIDE; Shin-ichiro UMEDA; Hiroshi YAMAZAKI; Yoshiki TAKAHASHI; Yoshiaki TERAUCHI; Toshihiko FUJII; Tetsuya KAMATAKI

doi:10.2133/dmpk.17.164

SNP Communications

A Major Genotype in UDP-glucuronosyltransferase 2B15

Kenji TOIDE, Shin-ichiro UMEDA, Hiroshi YAMAZAKI, Yoshiki TAKAHASHI, Yoshiaki TERAUCHI, Toshihiko FUJII, Tetsuya KAMATAKI

著者情報

キーワード: co-factor binding region, novel SNP, SSCP, and cis-4-hydroxytamoxifen glucuronidase

ジャーナルフリー

2002 年 17 巻 2 号 p. 164-166

DOI https://doi.org/10.2133/dmpk.17.164

詳細

抄録

  A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations.
  The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5′-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3′.
  This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.

責任著者(Corresponding author)

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