Novel Single Nucleotide Polymorphism of UGT1A7 Gene in Japanese

抄録

  We sequenced exon 1 of the UDP-glucuronosyltransferase (UGT) 1A7 gene from 52 Japanese cancer patients. Four single nucleotide polymorphisms (SNPs) were found. Three of them caused UGT1A7^*2 and UGT1A7^*3. A novel SNP (98973G>C) causing amino acid substitution (Ser¹⁴¹Cys) was found. The sequence is as follows: SNP, 050824FujitaK002; GENE NAME, UGT1A7; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5′-TAAAGGAGAGTTG/CTTTTGATGCAGT-3′. One out of 52 cancer patients was heterozygous for the variant allele, resulting in the allele frequency of 0.96%. The patient did not possess UGT1A7^*2 or UGT1A7^*3.