抄録
It has been reported that some transporters are located on the blood-brain and blood-cerebrospinal fluid barriers to exclude their substrates from the central nervous system. In this article, the molecular mechanism for the vectorial transport of xenobiotics is summarized particularly focusing on our own studies. In addition to MDR1 P-glycoprotein, we could suggest the significant role of multidrug resistance associated proteins in the drug disposition in the central nervous system. Moreover, the role of organic anion transporting polypeptides and organic anion transporters is discussed in relation to the transport studies in the blood-cerebrospinal fluid barrier.
