Studies on the Metabolic Fate of Felodipine (IV) : Identification of New Metabolites of Felodipine in Rat

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Two novel metabolites of felodipine were isolated from rat bile or in an in vitro system using rat liver preparations. Their chemical structures were identified by comparative analysis with authentic samples.
Both metabolites were formed by ester hydrolysis of felodipine. One was a 3-carboxyl derivative and the other a 5-carboxyl derivative ; both were identified as having dihydropyridine structures and were shown to be major metabolites in rat plasma.