A Dog with Liver Cirrhosis Administered with Autologous Dedifferentiated Fat Cells (DFAT)

Abstract

An 8-year-old male American Cocker Spaniel was referred to the Nihon University Animal Medical Center due to increased serum liver enzyme activity and abdominal effusion. The dog was diagnosed with liver cirrhosis and portal hypertension by computed tomography and laparoscopic examination. Despite being treated with prednisolone and spironolactone, the dog developed uncontrolled abdominal effusion as a result of portal vein thrombosis and liver failure. Moreover, cell transplantation therapy was attempted six times using autologous dedifferentiated fat cells (DFAT) harvested from the falciform adipose tissue of the dog on a previous laparoscopic examination. No adverse effects