A three-year-nine-month-old uncastrated male French bulldog (13.1 kg body weight) that had developed skin pruritis came to the authors’ veterinary hospital after medication with a generic drug of ciclosporin capsule formulation for one week. Skin symptoms at the first examination were erythema, pigmentation, and alopecia in the lower jaw, and erythema on the palm or sole of every foot. Based on results of various dermatological examinations, this condition was considered probably as atopic dermatitis and pyoderma. Medication with the ciclosporin generic drug was continued for an additional three weeks. Cefalexin was also administered for three weeks. The pyoderma was cured, but the atopic dermatitis symptoms were not improved by these medications. The blood level (trough value) of ciclosporin was found: it was under the detection limit or 30 ng/ml. Ciclosporin was then withdrawn. A cream formulation of prednisolone was applied externally, but the symptoms worsened thereafter. Therefore, ciclosporin was re-administered to achieve a good remission with the brand-name product, which contained a microemulsion preconcentrate of the drug. Results suggest that, in some dogs, different drug designs and products with different ciclosporin formulations (microemulsion or not) exhibited different pharmacokinetics.

Three cats presenting with anemia were diagnosed with myeloma-related disorders by bone marrow examination. Bone marrow smears showed increased numbers of plasma cells, mainly proplasmacytes, in the first two cases and mature myeloma cells in the third case. All three cases were treated with melphalan and chlorambucil. The first two cats died on days 71 and 82, respectively, and the third cat died on day 288. Our results suggest that differentiation of plasma cell morphology using proplasmacytes and mature myeloma cells may provide a new prognostic indicator for myeloma-related disorders in cats.

An 8-year-old male American Cocker Spaniel was referred to the Nihon University Animal Medical Center due to increased serum liver enzyme activity and abdominal effusion. The dog was diagnosed with liver cirrhosis and portal hypertension by computed tomography and laparoscopic examination. Despite being treated with prednisolone and spironolactone, the dog developed uncontrolled abdominal effusion as a result of portal vein thrombosis and liver failure. Moreover, cell transplantation therapy was attempted six times using autologous dedifferentiated fat cells (DFAT) harvested from the falciform adipose tissue of the dog on a previous laparoscopic examination. No adverse effects