Juntendo Medical Journal
Online ISSN : 2759-7504
Print ISSN : 2187-9737
ISSN-L : 2187-9737

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Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network
SAKI ASANOAKITOSHI OGAWA TAKAHIRO OSADASATOSHI OKAKOJI NAKAJIMAYASUSHI OSHIMASAKAE TANAKAHIDEYOSHI KAGAYOSHIFUMI TAMURAHIROTAKA WATADARYUZO KAWAMORISEIKI KONISHI
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ジャーナル オープンアクセス 早期公開

論文ID: JMJ24-0044-OT

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In this study, we observed that insulin resistance is linked to a reduction in grey matter volume in the default-mode and limbic networks of the cerebral cortex in older adults. Additionally, we found that the paraventricular nucleus of the hypothalamus is significantly functionally connected to these two cortical networks. Our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus.

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