Abstract
Since the study of Alloxan diabetes by H. R. Jacobs (1937), researches on the experimental diabetes made a dramatic progress. In order to determine experimentally what kind of toxicity alloxan has upon blood elements, I measured Heinz's body.
1) Analysis, by the in vitro formation method of Heinz's body
2) Analysis, by the in vitro accelerated formation method of Heinz's body i) Experiment with normal saline with alloxan added.
ii) Experiment with serum with alloxan added
In above-mentioned conditions, Heinz's body shows a tendency to a slight increase only.
For this result alone, I cannot declare with surety that alloxan is a remarkable blood toxin in so far as Heinz's body is concerned.
If we assumed that alloxan might be a diabetogenic agent, we cannot explain solely with alloxan the phenomenon that in clinical diabetes a high acceleration of Heinz's body formation is found; other noxae than alloxan may be responsible for this phenomenon.
