歴代雌雄甲状腺末投与Wistar系シロネズミ子孫 (F₁-F₂) に関する研究

抄録

Comparative studies on the rats were undertaken by administering the thyroid gland powder to successive generations. These rats were offsprings of F₁ ; 25 cases, F₂ ; 19 cases, F₃ ; 21 cases, F₄ ; 25 cases cases and F₅ ; 48 cases respectively. Estimations were made of body weight, histological examinations, tissue measurements of the thyroid and pituitary glands plasma PBI, total blood cholesterol and I¹³¹ uptake of the thyroid gland. There Comparative studies were made with 25 control rats.
The results are summarized as follows :
1. The growth weight of offsprings of F₄ and F₅ male groups was show as compared with the control.
2. In the thyroid glands of offsprings, the histological findings showed a smaller follicular size, reduced collagen quantity, increased eosinophilic staining with marginal vacuolization, and an increased (length) of follicular cells.
As to follicular formations, the number of cells tended to be less. However, the cellular area of follicles and the length showed a tendency as to increase generations followed.
3. In the pituitary body, these offsprings showed basophilia and eosinophilia but with basophilic swelling.
4. Serum PBI showed an increasing trend with successive generations.
5. Total blood cholesterol did not show any definite change in the offsprings.
6. Thyroid uptake of I¹³¹ of one and 24 hour values were increased as compared with the controls in both F₁ and F₂.
The above findings seem to indicate the increasing hyperfunction of the thyroid when the extract was administered on rat offsprings for successive generations.