Thiazide系降圧利尿剤による糖質代謝異常
1964 年 40 巻 4 号 p. 277-280,271
詳細
1964 年 40 巻 4 号 p. 277-280,271
In patients with hypertension and other diseases treated with thiazide derivatives for hypotensive and diuretic purposes, we observed decreased glucose tolerances in comparison with those before treatment. When thiazide diuretics were withdrawn, glucose tolerances were found to recover rapidly to normal. Oral tolbutamide test in these cases showed the blood sugar response curves between those in normal persons and in diabetics, suggesting disturbances in carbohydrate metabolism due to insulin deficiency.
