Anabolic Steroidのラット骨系統の代謝に及ぼす作用

抄録

Effects of an anabolic steroid, 4 Chlorotestosterone Acetate (4 CLTA), on the metabolism of the rat bone system were studied by a 20-day daily intraperitoneal injection of its even dose of 0.5mg in respective of the body weight of the rats, which were devided into two groups according to their weight ; of about 70g (group A), about 100g (group B) and their untreated controls.
i) An evident increase in the body weight compared with the control was observed after the 10th day in group A, and the 15th day in group B, and the difference between the average of the test group was estimable with P. value of 5%.
ii) Tibia of the test group had larger major axis and wet and dry weight and lower water content than the control with an estimable difference with P. value of 5%. But little estimable difference between the two average were observed in the minor axis.
iii) Protein and lipid contents of femur of the test group were higher than those of the controls. Their sampling could not be obtained because the materials were minced together in each group.
iv) Rediograph of Tibia was darker in the tested group especially at the epiphysis. v) Both net weight and content (% of the dry weight) of total ashes, and also their Ca, P and Mg were estimated to be larger with P. of 5%; Percent Ca, P and Mg of the total ashes had an estimable difference in the case where only Ca and the remainder were negligible.
vi) Physico-chemical properties of tibia, the means of appearent specific gravity, bulk specific gravity, Vicker's hardness and modulous of elasticity were higher while porcity and water absorption were lower with P. valtue of 5%.
vii) Histological findings of epiphyseal cartilage of the test group showed the promoted growth of the bone, showing regularity and conciderable thickness of the rod shaped cells.
viii) Promoted metabolism of condroitin sulfate A and C was detected histochemically in epiphyseal and articular cartilage of the test group.