上皮小体機能の研究

特に実験的上皮小体機能異常時における胆汁Ca無機P.クエン酸, 並びに肝核酸の消長について

抄録

The contents of calcium, inorganic phosphorus, citric acid in the serum and the bile were determined, and the changes of calcium and phosphorus in the bile were studied by isotopic technique in the biliary fistulated dogs with parathyroidal disturbance. And to observe the influence of parathyroidal function on the liver, the contents of nucleic acid were determined in the Wistar-strain rats affected with parathyroidal disorder.
The condition of hyper or hypofunction of the parathyroid gland was affected by the administration of parathyroid hormone and by surgical extirpation of parathyroid gland and by a low Ca and high phosphorus diet during 6 months.
Whenever there was hyperfunction of the parathyroid gland, hypercalcinemia, hypophosphatemia and hypercitremia were observed. Where as hypocalcinemia, hyperphosphatemia and hypocitremia were observed when the parathyroid gland was in a hypofunction state as compared with control.
On the other hand, the excretion of the bile Ca, citrate was increased and ⁴⁵Ca-excretion of the bile at the trace experiment was found to be 7 times increased as compared with control under the hypofunction condition.
It is reasonable to conclude that the increase of the citrate contents in the blood is caused by nephrectomy, but a remarkable increase of the citrate in the bile was found by the administration of parathyroid hormone after nephrectomy.
The excretion of calcium and citrate in the bile was found to be increased, especially ⁴⁵Ca-excretion which was one-half more than the control.
The contents of nucleic acid in the livers and kidney's of the Wister-strain rats with parathyroidal function disorders were determined to assume the influence of parathyroidal function upon the liver.
No significant difference was observed in the hepatic DNA contents between the normal rats and the hyperparathyroidal rats whose condition was induced by the administration of parathyroid hormone or by the nephrectomy.
It is considered that the difference of the influence on liver is caused by the methods which induce the disorder of parathyroidal function.
From the above-mentioned results, the author supposed that the biochemical change of calcium, inorganic phosphorus and citric acid and nucleic acid metabolism in the serum and bile indicated the strong influence of the parathyroid gland on the liver and kidney, and thus, proposed that there is an intimate correlation between the liver and parathyroid gland.