抄録
The rapid calcium infusin test (Goldsmith, R.S. et al. 1962) was evaluated in 3 normal subjects, 6 patients with parathyroid disorders, 12 patients with urolithiasis and 12 patients with various other diseases. Twenty-five milliliter of 2% calcium chloride solution was infused intravenously over a ten-minute period starting at 9 a.m. and the response of urinary phosphate excretion to calcium infusion was investigated for 3 hours.
All normal subjects, 10 patients with urolithiasis and 8 patients with various other diseases responded to calcium infusion, but a patient with hyperthyroidism and 2 patients with urolithiasis showed delayed responses to calcium infusion. The phosphaturic rhythm was unaffected by calcium infusion in a patient with renal tubular acidosis, a patient with Fanconi's syndrome, 3 hypoparathyroid patients and a patient with multiple myeloma who had severe impairment of renal function. The abnormal spontaneous phosphaturic rhythm, i.e. a progressive fall in phosphorus excretion, was observed in a patient with acromegaly and a patient with hypercalcemia of unknown etiology under corticosteroid therapy. A hyperparathyroid patient associated with adult Fanconi's syndrome showed a decreasing Up/Ucr ratio following calcium infusion, though his spontaneous pattern was not ascertained.
The fall in urinary phosphorus excretion below the control level within 3 hours after calcium infusion may be considered as a normal response to the rapid calcium infusion test, when calcium chloride is infused instead of calcium glucoheptonate.
