抄録
n the patients with cervical cancer undergoing extensive panhysterectomy, the effects of anabolic steroid on the protein metabolism following operation were observed. Thirty cases treated in our clinic were studied in this investigation. The intake and output of nitrogen were estimated exactly for 14 days after operation. Furthermore, protein patterns, nitrogen, creatinine and electrolytes in serum were measured pre- and postoperatively. The results were as follows :
1) Methenolone enanthate (ME) given on the first day after operation reduced the extent of the post-operative negative nitrogen balance significantly. Also, the shortening of catabolic phase compared with the control group was observed.
2) Amino acids preparation given for 3 days after operation did not cause any significance in the decrease nitrogen output or in the increase of nitrogen balance. This suggested that most of the amino acid preparations that were given were excreted without utilization ofprotein metabolism.
3) The group given ME plus amino acids preparation at the early postoperative period also indicated a significant decrease of nitrogen excretion and a significant increase of nitrogen balance. It seemed that anabolic steroid accelerated metabolic utilization of given amino acid preparations.
4) Higher doses of anabolic agents (ME + Methenolne acetate) given preoperatively were more effective in the decrease of nitrogen excretion and in the increase of nitrogen balance than that of other groups.
5) Administration of anabolic steroid and/or amino acid preparations did not cause in the serum protein patterns, serum creatinine and serum electrolytes followin operation.
6) Changes in NPN, amino-N and urea-N suggested that these steroids had anabolic effect on the protein metabolism.
7) Recovery of body weight was maintained by the administration of anabolic steroid. Water and sodium retention were not observed through the postoperative period in all groups.
8) No clinical side effects were observed in all cases administered with anabolic steroid.
From these results, the author concluded that the administration of anabolic steroid in preoperative or early postoperative period was effective on the protein metabolism following extensive panhysterectomy in the patients with cervical cancer.
