抄録
This part dealt with the study of the effects of anabolic steroid on the protein metabolism in the patients with cervical cancer treated by radiation therapy. Twenty cases as anabolic steroid group and 15 cases as control group were used in this investigation. All cases received 3200-4000 rad of telecobalt and 6000mg of Radium in total doses. The anabolic steroid (AS) group was given Methenolone enanthate 100mg per week or 19-Nortestosterone furylpropionate 25mg per 3 days from the beginning of the radiation course. The daily intake and output of nitrogen were estimated exactly before and during radiation therapy. Moreover, protein patterns, nitrogen, electrolytes in serum and body weight were measured at the same time.
The results were as follows :
1) Before the radiation therapy, well nourished patients with cervical cancer (more than 60g of protein intake per day) showed positive nitrogen balance of 3-7g/day.
2) 60Co irradiation caused a decrease in the intake of nitrogen and a drop in the nitrogen balance. Therefore, in some patients of the control group, slight negative nitrogen balance occurred soon after starting the telecobalt therapy.
3) In the AS group the decreasing rate of nitrogen intake was much less than that in the control group. The alteration of nitrogen balance compared with that in pre-radiation period was minimum.
4) Thereafter, on proceeding with telecobalt therapy, the nitrogen intake and the nitrogen balance approached, slightly and slowly, the pre-radiation levels.
5) In Radium therapy following60Co irradiation, the intake of nitrogen decreased again and the nitrogen balance remarkably tended to be lower in the control group.
6) In the AS group the extent of nitrogen balance was much more than that in the control group during all courses of telecobalt and Radium therapy.
7) Body weight in the control group showed about 5% decrease at the end of radiation therapy, but in the AS group it increased slightly and gradually.
8) Slight decrease in the total protein and albumin was observed during radiation therapy in the control group. The AS group did not show any significant change.
9) Serum amino-N and urea-N in the AS group were both lower than those in the control group through radiation therapy.
10) Changes in concentration of serum sodium and chloride were not remarkably obserbed, but in potassium, the AS group showed a slightly lower level than the control group.
The author concluded that anabolic steroid was useful for the protection of catabolism in the patients with cervical cancer during radiation therapy.
