Abstract
The relationship between the effects of the catecholamines and the thyroid hormones have been studied for more than 100 years. The mechanism of this interrelationship has been the subject of many investigations, but the results have been divergent and have not led to any generally accepted explanation.
We confirmed in the previous experiment that reserpine and guanethidine treated hyperthyroid patients showed definite clinical improvement, for example, decrease of palpitation and sweating, while no changes in the basal metabolic rate and uptake of radioactive iodine was observed. Furthermore, no potentiation was found in the effects of catecholamines on the phosphorylase activity in the hyperthyroid rat heart. It was therefore considered desirable to study this relationship between the catecholamine and thyroid hormone in two parts : firstly the relationship in the metabolic system, and secondly the relationship in the cardiovascular system.
This investigation was undertaken to determene the effect of adrenaline on the carbohydrate metabolism in the hyperhtyroid rat muscle using a hind quarter preparation technique.
