Studies on the Glucose Tolerance and Glucose-insulin Responce of Hypophysectomized Rats

Abstract

The significance of the hypophysis in the experimental diabetic state of animals was established by the classical papers of Houssay and Young in the 1930's and 1940's.
Pfeifer and associates have reported that hypophysectomy on dogs resulted in a reduction of serum ILA. (epididymal fat pad) and of blood sugar. In this paper we attempt to ascertain that a reduction of serum insulin by radioimmunoassay will occur after hypophysectomy on rats.