Abstract
Effect of salivary gland-ectomy on the proliferative response of proximal epiphyseal cartilage of the tibia of hypophysectomized rat to the growth hormone was investigated using young adult male rats of 60days of age. Changes of the cells in the basophilic and vesicular zones, the decrease in the width of the cartilage plate and the reduction of osteogenesis in the tibia of the hypophysectomized animal showed a tendency of recovery to normal states following growth hormone replacement. Those morphological features in both hypophysectomized and salivary gland-ectomized animals did hardly regain their normalities as the result of growth hormone administration. Nevertheless, it was learned that the affected features in question, excepting the suffered osteogenesis, were in significant measure brought to recovery by injection of the preparation of salivary-gland hormone, Parotin.
