抄録
A new procedure for estimating thyroxine secretion rate by checking the changes in the level of alkaline phopshatase in the chicken serum is described, and is compared with the goiter prevention technique. Five and 9-week-old cockerels and pullets were used, divided into several groups. All of the birds except the last group, received 0.1% thiouracil in diet and the graded dose of L-thyroxine for 10 days. The group average of thyroxine secretion rate was estimated by solving the regression equation between the percentage of the finalvalue to theinitial value of alkaline phosphatase unit (Y) and thyroxine dose (X), giving the initial percentage of the enzyme of non-thiouracil-treated control group to Y.
The estimates of thyroxine secretion rate obtained by the new method roughly correlated to those derived from the goiter prevention assay.
