Endocrine Journal
収録数 6,264本
(更新日 2022/12/05)
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
2021 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
69 巻 (2022) 11 号 p. 1285-1293
Thyrotropin receptor antagonists and inverse agonists, and their potential application to thyroid diseases もっと読む

Molecular research on agonists / antagonists / inverse agonists in a variety of G-protein coupled receptors (GPCRs) has long attracted robust attention of endocrinologists. In this issue, Dr. Nagayama and Dr. Nishihara contributes an encyclopedic, well-organized article on the update of antagonists / inverse agonists research around the thyrotropin receptor (TSHR), providing us with promising therapeutic potential for Graves’ hyperthyroidism, non-autoimmune hyperthyroidism, thyroid cancer and resistance to thyroid hormone.

69 巻 (2022) 10 号 p. 1159-1172
Therapeutic role of mesenchymal stem cells (MSCs) in diabetic kidney disease (DKD) もっと読む

It has long been recognized that uncontrolled high blood pressure, dysmetabolism of glucose and lipids, and sustained inflammation and fibrosis are involved in the pathophysiology and progression of diabetic kidney disease (DKD) in an extremely complexed manner. It is therefore exactly a herculean issue to accurately identify patients with higher risks than we would imagine for end-stage renal diseases (ESRDs). In the October issue, Dr. Xu Ning and colleague provide an attractive review article focusing on potentials of mesenchymal stem cells (MSCs) for the treatment of such an intractable medical condition.

69 巻 (2022) 9 号 p. 1053-1060
Effects of tubastatin A on adrenocorticotropic hormone synthesis and proliferation of AtT-20 corticotroph tumor cells もっと読む

Epigenome-based drugs such as inhibitors against DNA methyltransferases (DNMTs) and histone deacetylase (HDACs) have long been employed for the treatment of a variety of malignancy and pre-cancer status. In this issue, Dr. Rie Hagiwara and colleague provide a convincing data set of in vitro experiments demonstrating a selective HDAC6 inhibitor, tubastatin A substantially suppresses the growth of as well as the ACTH secretion from a murine corticotroph cell line, AtT-20. The present study may open a fresh avenue for brand-new therapeutics in humans on pituitary neuroendocrine tumors including Cushing’s disease.

69 巻 (2022) 8 号 p. 881-896
Advances in understanding of phosphate homeostasis and related disorders もっと読む

Science and clinics on phosphate homeostasis are no doubt an authentic, royal road to endocrinology. As most of readers of Endocrine Journal well recognize, basic scientists and endocrinologists in Japan have made a huge contribution to the molecular medicine on fibroblast growth factor 23 (FGF 23) in this academic field. To STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY in this issue, Dr. Michigami contributes an extensive, well-organized article on the recent research progress in phosphate homeostasis and related disorders with a particular emphasis on FGF 23, providing us with an invaluable perspective for cutting-edge area of bone-mineral endocrinology.

69 巻 (2022) 7 号 p. 739-748
New perspectives on obesity-induced adipose tissue fibrosis and related clinical manifestations もっと読む

Dynamic remodeling of adipose tissue plays a critical role in the pathophysiology of obesity disease. In this article, Dr. Yutaka Hasegawa elegantly updates the research on the molecular mechanism whereby adipocytes interact with non-adipocytes during the course of adipose dysfunction and fibrosis in obesity. This review does provide us with invaluable perspective for endocrinology-based obesity science.

月間アクセス数ランキング (2022年11月)