Abstract
Na-sulfaacetylthiazole, 0.5g/kg body weight, was injected into immature and adult rats to produce obstructive nephropathy. Necrotic changes in the myocardium were found in all of the 9 adult rats of about 120 days of age, whereas no such changes occured in immature animals of about 40days of age. Thyrocalcitonin, 50mMRC units a day injected subcutaneously for one week, completely inhibited the occurrence of such myocardial lesion in adult animals, as did parathyroidectomy performed one week previously. Serum calcium was decreased from the normal adult level in thyrocalcitonin treated or parathyroidectomized animals but not in untreated immature rats. Thyrocalcitonin appears to have some effect on cardiovascular system in addition to the known effect on the bone.
