抄録
The authors previously noted a more significantly decreased response of lipoprotein lipase activity to dextran sulfate injection in diabetic patients than in normal subjects and suggested that the lowered plasma lipoprotein lipase activity may contribute to hypertriglyceridemia in diabetic patients. In the present report the authors have studied on human subjects and rats with and without diabetes, the regulation of lipoprotein hpase activity in postdextransulfate plasma and tissues following administration of glucose or fat. In normal subjects the response of plasma lipoprotein lipase activity to injected dextran sulfate one hr. after feeding or oral glucose administration was significantly higher than the response after an over night fast. In diabetic patients, however, the difference between feeding or glucose administration and over night fast was insignificant. In normal rats the increase of tissue lipoprotein lipase activity to intravenously administered glucose was significant in adipose tissue and insignificant in muscles. After intravenous fat administration no significant changes were observed either in aciinose tissue or in muscles. In alloxan diabetic rats decrease in activity of lipoprotein lipase was significant in adipose tissue, but insignificant in heart muscle and diaphragm compared with normal rats. From the facts above it is suggested that markedly elevated plasma lipoprotein lipase activity after glucose loading in normal subjects is released from tissue in response to intravenously administered dextran sulfate. The authors have also discussed the probability of induction of lipoprotein lipase in adipose tissue by the metabolic effects of glucose and/or insulin.
