抄録
Short-(3.5hr) and long-term (3 days) effects of ACTH in vivo on the incorporation of 3H-leucine into cell fractions from rat adrenal glands were examined, with special regard to effects of the hormone on the rate of the amino acid incorporation into submitochondrial fractions. An injection of ACTH caused a significant increase in the rate of the radioactive amino acid incorporation into the inner membrane and soluble matrix fractions of adrenal mitochondria within 3.5 hr while no significant effect of ACTH administration was observed in the other subcellular fractions. Injections of ACTH for consecutive 3 days resulted in the elevated rate of the incorporation into all subcellular fractions except into the acid-soluble fraction. Physiological significance of the results obtained was discussed with respect to the steroidogenic effect of ACTH.
