Abstract
1) The effects of PMS on female sexual organ weights of immature mice were studied.
2) In statistical analysis, we chose the cubic roots of both ovarian weights and uterine weight as the metameter of the response.
The relationships between logarithm dose and metameter was found to be linear and the reproducibility was confirmed.
These results will be valuable for the purpose of quantitative assay.
Acknowledgement The authors wish to thank Prof. Y. Ito and Mr. B. Kobayashi, of the Institute of Physiological Chemistry, Department of Pharmacy, Faculty of Medicine, Tokyo University.
Thanks are due also to Dr. T. Nomura of the Central Laboratory for Experimental Animals, for supplying ddN strain of mice used in these experiments.
Further we express our gratitudes to Mr. R. Marusawa of Sankyo Co. Ltd., who gave kind discussions about statistics.
The expenses of the work was aided partly by the Scientific Research Funds from the Ministry of Welfare.
