1. Contents of various carbohydrate in liver and blood sugar values are measured with the purpose to find out the effect of mesoxalate on the deposition of glycogen in livers of normal and alloxan diabetic rabbits.
2. Injection of mesoxalate solution accelerates the deposition of glycogen in both livers of normal and of diabetic rabbits, and in the latter case the deposition of glycogen is more significant.

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1) The effects of PMS on female sexual organ weights of immature mice were studied.
2) In statistical analysis, we chose the cubic roots of both ovarian weights and uterine weight as the metameter of the response.
The relationships between logarithm dose and metameter was found to be linear and the reproducibility was confirmed.
These results will be valuable for the purpose of quantitative assay.
Acknowledgement The authors wish to thank Prof. Y. Ito and Mr. B. Kobayashi, of the Institute of Physiological Chemistry, Department of Pharmacy, Faculty of Medicine, Tokyo University.
Thanks are due also to Dr. T. Nomura of the Central Laboratory for Experimental Animals, for supplying ddN strain of mice used in these experiments.
Further we express our gratitudes to Mr. R. Marusawa of Sankyo Co. Ltd., who gave kind discussions about statistics.
The expenses of the work was aided partly by the Scientific Research Funds from the Ministry of Welfare.

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1) Young male albino rats, mongrel dogs, and human subjects were employed to examine the effect of exogenous injection of oxytocin on the pituitary-gonadal system.
2) By the injection of oxytocin, the pituitary-gonadal system is strongly stimulated, and the secretion of pituitary gonadotrophin markedly increases judged by the urinary output of pituitary gonadotrophin, the chromatographic fractionations of urinary 17-ketosteroids, and by the histological findings of the adenohypophysis and the gonads.
3) Brief discussions are made on the role played by the hypothalamic pituitary neurosecretion with regard to the stimulation of the anterior pituitary in the natural stress response.

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1) Chlorpromazine inhibits the appearance of the neurosecretion of the hypothalamus and prevents the release of pituitary adrenocorticotrophic and gonadotrophic hormones under conditions of surgical stress.
2) Chlorpromazine does not hinder the actions of exogenous Pitressin and Pitocin which stimulate the release of ACTH and gonadotrophin respectively.
3) Brief discussions have been made on the role of vasopressin and oxytocin in the liberation of pituitary trophic hormones.

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By purifying the dried powder, which was precipitated from the human saliva by the addition of acetone, as shown in Fig. 1, parotin-like protein was isolated and named “Saliva-parotin”.
Its isoelectric point was pH 3.4 and its purity in the electrophoretic analysis was 72.7%(by the ascending).
It gave all the color reactions of proteins and precipitated with acids or heavy metals, but did not coagulate in aqueous solution by heating.
By paper partition chromatogrophy of the hydrolyzate of saliva-parotin seventeen kinds of amino acids were identified. Saliva-parotin possesses an entirely the same biological action as parotin; decrease of serum calcium level, promotion of calcifying the incisor dentine, increase of the number of circulating leueocytes and rise of the bone marrow temperature were clearly observed in rabbits. The fall of the blood pressure in an anesthetized dog was recognized with an insufficiently purified preparation, but not in the case of the preparation with 72.7% purity.
Acknowledgement. The authors greatly appreciative of the cooperation of Dr. H. Takatani, Tasaka Internal Medical Department, University of Tokyo, Prof. S. Huse and Mr. N. Matsuda, Department of Dental Surgery, School of Medicine, Gunma University, Mr. H. Takigawa, Endocrinological Laboratory, School of Medicine, Gunma University, and Mr. Y. Morioka, Teikoku Hormone Manufacturing Co., and co-workers in this study.

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As the first step of the investigation on the mechanism of the manifestation of the dairy performance, he structural changes of mammary glands of three goats with different performances were studied on five stages in the second lactation and on four stages in the third respectively. Results obtained are briefly summarized as follows.
1) As there was no significant difference in the tendency of decrease in daily production after the maximum period between individuals and between lactations, the peak production and the duration of lactation, especially the former had a great influence upon the total yield.
2) In the structure of the mammary gland on the 100th day in the pregnancy, ther were not so remarkable differences between individuals and between pregnancy orders, but the proliferation of alveolus was rather advanced in lower producers.
3) In the structure of the mammary gland during lactation such characters as the number of alveolus per lobules, the sectional area of alveolus and the number of glandular cell per section of alveolus decreased with the progress of stages in the two lactations. Whereas the number of alveolus per sightfield and the height of glandular cell increased, and the coefficient of sectional area of alveolus hardly changed. Particularly, the tendency of decrease of the sectional area of alveolus was similar to that of the milk production.
4) Such characters as the sectional area of alveolus, the number of glandular cell per section of alveolus and the number of alveolus per lobulus may be important characters of mammary qualities which relate to milk production in consideration on the differences between individuals and between lactations. And further, it seems necessary for manifesting high production that these characters are as large as possible, and decrease very slowly after the maximum period.
The authors wish to express their hearty thanks to Dr. K. Sasaki for his encouragement and to our laborants for their good care in the management of animals.
This work was carried out through a grant from the Research Fund of Educational Ministry in Japan.

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Using normal and adrenalectomized mice, the effects of epinephrine and norepinephrine on pentothal and barbital anesthesia were investigated.
1. The anesthetic dose of pentothal in normal mice was reduced by simultaneously given 0.3γ per 10g. b. w. of epinephrine, but the duration was not altered.
2. The anesthetic dose of barbital in normal mice was not reduced by simultaneously given 0.3γ per 10g. b. w. of epinephrine, but tended to be reduced by the same dose of norepinephrine.
3. The induction time of barbital anesthesia in normal mice was not affected by 0.3 or 1.0γ per 10g. b. w. of epinephrine or norepinephrine. The duration was not altered by 0.3γ per 10g. b. w. of either of these hormones, but tended to be prolonged by 1.0γ of norepinephrine. In this case pronounced death ensued.
4. The induction time of barbital anesthesia in adrenalectomized mice was not affected by 0.3γ per 10g. b. w. of epinephrine or of norepinephrine. The duration could not be determined, since all the animals in both the control and experimental groups suffered death.
Acknowledgment. The authors wish to express their appreciation for the kindness of Dr. M. L. Tainter, Sterling-Winthrop Research Institute, U. S. A. in supplying epinephrine and norepinephrine.

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