Effect of Adrenergic-blocking Agents on Plasma Growth Hormone Response to L-5-Hydroxytryptophan (5-HTP) in Man
1974 年 21 巻 6 号 p. 493-497
詳細
1974 年 21 巻 6 号 p. 493-497
The effects of adrenergic-blocking agents on plasma human growth hormone (hGH) response to L-5-hydroxytryptophan (5-HTP) were studied in man. Oral administration of 150mg of 5-HTP caused a rise in plasma hGH in most of the normal subjects tested, with peak hGH levels of 14.6±2.6ng/ml (mean±SEM). Concomitant administation of propranolol, a beta adrenergic-blocking agent, significantly increased plasma hGH response to 5-HTP. On the contrary, stimulation of growth hormone release by 5-HTP was partially but significantly inhibited by i.v. infusion of phentolamine, an alpha adrenergic-blocking agent. Possible mechanisms by which adrenergic-blocking agents affect plasma hGH response to 5-HTP are discussed.
