Effects of Calcitonin and Other Hormones on Bile Calcium Excretion in Thyroparathyroidectomized Rats

抄録

The effects of calcitonin (CT) and other hormones on the bile calcium excretion after a single intraperitoneal administration of calcium (4.0mg/100g BW) was investigated in thyroparathyroidectomized rats. Porcine, salmon, and synthetic eel CT (80MRCmU/100g BW, respectively) markedly increased the bile calcium excretion in comparison with that of calcium-administered rats. Tetragastrin (7.5μg/100g BW), and insulin (50mU/100g BW) did not alter significantly the bile calcium excretion, while epinephrine (100μg/100g BW), glucagon (50μg/100g BW), and parathyroid hormone (25U/100g BW) increased significantly. The increasable effect of CT on the bile calcium excretion was significantly prevented by epinephrine (10 and 100μg/100g BW). The present results suggest that the bile calcium excretion may be increased by the hormones which causes the elevation of cyclic AMP in the liver cells of rats.