Circulating Immune Complexes in the Serum of Diabetes Mellitus in Childhood by a Modified ¹²⁵I-C_1q Binding Test

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The ¹²⁵I-C_1q binding test for the detection of soluble immune complexes in native unheated human serum was applied to the study of sera from 52 patients with diabetes mellitus in childhood. This radiolabeled C_1q binding testis more sensitive and reproducible among the various methods proposed for the detection of immune complexes.
The ¹²⁵I-C_1q binding activity in 52 sera from diabetes mellitus in childhood was 9.47±0.36% compared to 6.94±0.74% in normal controls.
¹²⁵I-C_1q binding values in diabetes mellitus in childhood were significantly higher than normal controls. Slight high values were seen in 3 patients with positive anti-DNA-antibodies in diabetes mellitus in childhood. ¹²⁵I-C_1q binding was not significantly increased in patients with positive antithyroid antibodies and insulin antibodies. There was no significant correlation between the duration of diabetes and ¹²⁵I-C_1q, binding activity.