Distribution of VIP Neurons in the Peripheral and Central nervous System
1980 年 27 巻 Supplement 号 p. 23-30
詳細
1980 年 27 巻 Supplement 号 p. 23-30
Vasoactive intestinal polypeptide (VIP) was isolated from porcine intestine in 1970 by Said & Mutt (1970). Characterization showed that it consists of 28 amino acids (Mutt & Said, 1974). Antibodies were raised against the peptide (Said & Faloona, 1975) and radioimmunological determinations revealed high concentrations of VIP in the gastro-intestinal tract (Polak et al., 1974 ; Said, 1975), in neural cell lines (Said & Rosenberg, 1976) and in the central nervous system (Bryant et al., 1976 ; Larsson et al., 1976b ; Said & Rosenberg, 1976). Immunohistochemical studies located the VIP-like immunoreactivity to gastro-intestinal neurons (Bryant et al., 1976; Larsson et al., 1976b ; Fuxe et al., 1977), cerebrovascular nerves (Larsson et al., 1976a) and central neurons (Fuxe et al., 1977 ; Larsson et al., 1976b).
The present paper gives a brief account of the distribution of VIP immunoreactive neurons in the central and peripheral nervous system as revealed by immunohistochemistry.
