1983 年 30 巻 5 号 p. 609-614
The maxium ouabain binding capacity in erythrocytes from 8 normal subjects and 14 patients with hyperthyroidism was assessed by measuring [3H]-ouabain binding. The mean value for maximum ouabain binding capacity was significantly lower in the patients than in normals (0.422±0.084 vs 0.671±0.095 pmol per 109 cells, p<0.001). Furthermore, a close inverse correlation was found between the ouabain binding capacity and serum T3 (r=-0.766; p<0.01) or T4 (r=-0.870; p<0.001) levels. These results suggest that the maximum ouabain binding capacity in erythrocytes may provide a useful index of the peripheral effect of thyroid hormone.