Plasma Growth Hormone (GH) Response to GH-Releasing Factor (SM-8144) in Children of Short Stature and Patients with GH Deficiency

抄録

Synthetic human GRF (hGRF (1-44) NH₂; SM-8144) was administered as an iv bolus to141normal children of short stature (NSC), 73 patients with severe idiopathic GH deficiency (IGD; group A), 30patients with mild idiopathic GH deficiency (IGD; group B), 29patients with secondary GH deficiency, 3patients with primary hypothyroidism, 21patients with Turner's syndrome and25patients with various other diseases. Their height was below normal for their age and sex, and they were all below25years old without obesity. The maximal GH responses (M±SEM) were 39.5±2.2, 7.2±0.9, 27.2±3.7, 5.2±0.8, 9.7±4.4, 25.1±2.8 and32.3±4.8ng/ml, respectively (significance from the NSC, ; p<0.05, ; p<0.001). The GH responses to hGRF were greater than those elicited by standard pharmacological tests. There was a negative correlation between bone age and peak plasma GH response to hGRF in patients with idiopathic GH deficiency (IGD) but not in normal children (NSC). In twenty-two percent of the patients with IGD in group A the response was above10ng/ml and in 57% of the patients with IGD in group B the response was above 20ng/ml, suggesting that a large percentage of patients with idiopathic GH deficiency lack hypothalamic GRF. The side effect of flushing was observed in 15.2% of all subjects.
These results indicate the potential usefulness of hGRF (1-44) NH₂ (SM-8144) in inducing GH release from the pituitary.