抄録
Using the immunoperoxidase and immunogold methods with specific antibody, we studied the atrial natriuretic polypeptide (ANP) in seven tumor tissues ofsix patients with adrenal pheochromocytoma. Light microscopically, the reactionproduct for ANP was observed in all seven tumor tissues. Intracytoplasmicimmunoreaction product for ANP was finely granular. In four cases studied withthe electron microscope, the immunogold stain for ANP was demonstratedin secretory granules of the tumor cells. A considerable amount of alpha-hANPimmunoreactive substance was also extracted from two tumor tissues (67.2 and 28.7pg/mg wet tissue). This is the first report of the human adrenal pheochromocytomathat contains immunoreactive ANP. These findings provide additional evidence for the multisecretory APUD cells of neural crest origin.
