Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Effect of Media Conditioned by Concanavalin A Activated Spleen Cells on Pancreatic Islet Cells
MANABU SAWADAKOJI NAKANOGOJI HASEGAWAJUNKO SETOGUCHIHIROFUMI SHIGETANAOTO NAKAMURATAKAHIRO KANATSUNAMOTOHARU KONDO
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1991 年 38 巻 1 号 p. 47-52

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The effect of media conditioned by concanavalin A-activated spleen cells (C-sup) on insulin release and its islet cell cytotoxicity were studied. In a functional study, C-sup significantly inhibited both basal insulin release and glucose-stimulated insulin release. Morphologically, C-sup had a destructive effect on isolated islets after 72h incubation. Islet cell cytotoxicity was shown by lactate dehydrogenase (LDH) release assay after 5 days incubation with C-sup in a dose-dependent manner. These results suggest that acceleration of the onset of diabetes in young diabetes prone (DP) Bio-Breeding/Worcester (BB/W) rats following the injection of C-sup may depend on the suppressive and cytotoxic effects of C-sup on pancreatic islet cells.
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© The Japan Endocrine Society
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