STUDIES ON THE SALIVARY GLAND HORMONES LABELED WITH I¹³¹3. EFFECT OF LIGATION OF SEVERAL BLOOD VESSELS ON THE DEGRADATION AND DISTRIBUTION OF I¹³¹-LABELED PAROTIN IN VIVO

Abstract

Effect of ligation of several blood vessels on the degradation and distribution of I¹³¹-labeled Parotin in rat was studied. The degradation of the labeled Parotin in vivo as measured by the per cent of the total administered radioactivity found in non-protein fraction of plasma was remarkably decreased following the ligation of celiac artery or of renal vessels.However, the least degradation of I¹³¹-Parotin in vivo was observed in the group where portal vein as will as celiac, superior mesenteric and inferior mesenteric arteries were ligated.
Significantly large retention of radioactivity was found in liver after the ligation of celiac artery and also after the ligation of renal vessels.It was suggested that very close correlations on the degradation and distribution of I¹³¹-Parotin exist between liver and kidney which were recognized to be the main sites of degradation of the labeled Parotin in vivo.