Abstract
The effect of small repeated intravenous administrations of alloxan (1-20mg per kg per day) on glucose tolerance was examined in 20 rabbits.
The intravenous glucose tolerance curves from 6 rabbits intravenously given 1mg per kg per day of alloxan for 5 or 10 days, were steeper than those from controls. And those from 3 rabbits treated daily with 10-20mg per kg of alloxan for 10 days or more showed lower slope, resembling the diabetic one. These tendencies were neither transitory nor progressive.
Mechanism of action of alloxan was discussed briefly. It was concluded that 1mg per kg per day doses of alloxan given intravenously, stimulated the function of beta cells and 10 nag per kg per day doses or more produced a damage to beta cells in pancreatic islets of rabbits.
