抄録
Immature ovaries transplanted to the spleen of gonadectomized immature rats of both sexes underwent an accelerated development within 15 days producing follicles of varying sizes and corpora lutea. This suggests that a minute amount of androgen or estrogen secreted by the gonad in immature animals is effective in exerting a regulatory influence on the hypophyseal gonadotrophic function.
Injections of minute doses of estrogen or androgen which were incapable of exerting any noticeable effects on the growth of sexual accessories (2.0μg daily of testosterone propionate or 0.03μg daily of estrone) were effective in inhibiting the above-mentioned postcastrational rise of gonadotrophic activity of the hypophysis in immature rats, as evidenced by the behavior of intrasplenic ovarian transplants.
It seems probable that a hormonal interrelationship between the anterior lobe of hypophysis and the gonad, like that demonstrated in mature rats, is in play in immature animals, at the blood levels of gonadal hormones and gonadotrophins much lower than those in mature animals.
