GESTATIONAL EFFECT OF ALLYLESTRENOL

抄録

1. Allylestrenol is complete oral and parenteral gestagen. It has all of the gestational effects of progesterone in the rabbits. This agent produces normal gestational proliferation of the endometrium, normal blastocysts, secure normal implantation and maintain the pregnancy in a normal manner to term.
2. Relative potency of the compound is about half time as active as progesterone when both are given parenterally and about 1/8 as active orally as progesterone is parenterally.
3. As allylestrenol is rather short acting, it is necessary to give it more than twice daily in order to bring about the successful result in maintaining pregnancy.
4. The compound is free from toxic effect and virilizing action on the mother and female fetuses.
5. Even large dose of allylestrenol does not inhibit the normal ovum tubal transportation.