Interleukin-1β Administered Intracerebroventricularly Stimulates the Release of Noradrenaline in the Hypothalamic Paraventricular Nucleus via Prostaglandin in the Rat

Abstract

We evaluated the effect of intracerebroventricular (icy) administration of interleukin (IL) -1β on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat. IL-1β increased rectal temperature at doses ranging from 300pg to 300ng, whereas it, at doses ranging from 3ng to 300ng, significantly stimulated the release of NA in the PVN measured by intracerebral microdialysis. The stimulatory effect of IL-1β on the release of NA was blocked by the subcutaneous injection of indomethacin. These findings suggest that IL-1β stimulates the release of NA in the PVN via prostaglandin, and that the release of NA in the PVN is not necessarily related to the increase in body temperature.