Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
Featured articles
Displaying 1-20 of 26 articles
  • Volume 71 (2024) Issue 5 Pages 437-445
    Cell-specific functions of androgen receptor in skeletal muscles Read more
    Editor's pick

    It is widely recognized that androgens play a crucial role not only in developing secondary sexual characteristics in men but in exerting protein anabolic effects as anabolic steroids. In this issue, Professor Yuuki Imai and Dr. Hiroshi Sakai contribute a sophisticated and insightful review on cell-specific functions of androgen receptor within skeletal muscles, particularly in satellite cells, myofibers and mesenchymal progenitors. A variety of indirect effects of androgens via extra-muscle tissue on skeletal muscle are also impressively highlighted.

  • Volume 71 (2024) Issue 4 Pages 335-343
    Phosphate-sensing mechanisms and functions of phosphate as a first messenger Read more
    Editor's pick

    Fibroblast growth factor 23 (FGF23) plays a critical role in regulating circulating phosphate level. To date, however, mechanisms whereby bone senses the change of blood phosphate level and regulates the production of FGF23 have been poorly elucidated. In this issue, Dr. Yuichi Takashi contributes an insightful review article focusing on such long-lasting enigmas. Our editorial team is sure that readers will be fascinated by the profound world of phosphate homeostasis via unique endocrine systems.

  • Volume 71 (2024) Issue 3 Pages 295-303
    Lung adenocarcinoma metastasis within a pituitary neuroendocrine tumor: a case report with review of literature Read more
    Editor's pick

    Dr. Koji Suzuki and colleague report in the March issue an extremely rare case of metastatic lung adenocarcinoma within a gonadotroph pituitary neuroendocrine tumor (PitNET), representing a considerably expeditious progression of a variety of neurological symptoms. This excellent report provides us with invaluable insight into diagnosis and therapeutics for coexisting primary and metastatic tumors in pituitary gland.

  • Volume 71 (2024) Issue 2 Pages 101-118
    Single-cell and spatial transcriptomics in endocrine research Read more
    Editor's pick

    As well known, endocrine organs including pituitary gland, adrenal gland and pancreatic islet of Langerhans et cetera consist of heterogenous cells, and pathophysiological interplay among hormone-producing cells and non-hormone-producing cells within tissue is crucial, at least in part, for molecular basis of a variety of endocrine diseases. In the February issue, Dr. Ryusaku Matsumoto and Takuya Yamamoto provide a comprehensive, fascinating review article focusing on the update of single-cell and spatial transcriptomics in endocrine research. Our editorial team has a firm belief that this review is a must-read for all dedicating clinicians and scientists on endocrinology.

  • Volume 71 (2024) Issue 1 Pages 23-29
    Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events Read more
    Editor's pick

    It is widely recognized that some cases of immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) result in life-threatening consequences including adrenal crisis and fatal diabetic ketoacidosis. In this issue, Dr. Tomoko Kobayashi and colleague contribute an insightful and well-organized review article on promising biomarkers to predict the onset of endocrine irAEs, particularly underscoring the mechanism-based management strategies and future prospect for pituitary and thyroid irAEs.

  • Volume 70 (2023) Issue 12 Pages 1123-1130
    Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells Read more
    Editor's pick

    It is well known that both Ca2+ and cAMP play critical roles in ACTH-driven cortisol production by adrenal fasciculate cells. However, the division of role for Ca2+ and cAMP in this paradigm still remains obscure. In the December Issue, Dr. Masahiko Kutsukake and colleague elegantly unraveled such a long-standing enigma via sophisticated cellular experiments, demonstrating that cortisol production under steady state is preferentially mediated by Ca2+, but cAMP also participates under stressful conditions where ACTH demand is increased to adapt exaggerated stress.

  • Volume 70 (2023) Issue 10 Pages 987-998
    Prediction-based prompt levothyroxine replacement to prevent a hypothyroid state after immune-related adverse events involving the thyroid gland Read more
    Editor's pick

    As well known, immune checkpoint inhibitors (ICIs) sometimes cause immune-related adverse events in the thyroid gland (thyroid irAEs). Dr. Ichiro Yamauchi and colleague conducted an elaborate retrospective cohort study demonstrating that patients with rapid-onset severe thyrotoxicosis as well as with positive TgAbs titers were highly likely to develop subsequent hypothyroidism. This study provides us with a message that expeditious replacement of levothyroxine is a crucial precaution against severely hypothyroid state.

  • Volume 70 (2023) Issue 9 Pages 851-866
    Unraveling the mysteries of hepatic insulin signaling: deconvoluting the nuclear targets of insulin Read more
    Editor's pick

    Complexity in action-specific resistance and hypersensitivity of hormones has long been recognized throughout the body. In particular, however, underlying molecular mechanisms of selective insulin resistance in liver are not yet fully elucidated. In the September issue, Dr. Takumi Kitamoto and Professor Domenico Accili provide an elegant, comprehensive review article on such a longstanding enigma.

  • Volume 70 (2023) Issue 8 Pages 771-776
    Deciphering Rho-associated, coiled-coil-containing protein kinase in diabetic nephropathy: small steps towards a giant leap Read more
    Editor's pick

    Unravelling the complexed molecular pathophysiology of diabetic nephropathy is no doubt a key to establish cutting-edge therapeutics against end stage renal diseases (ESRDs) and cardiovascular events. In this issue, Dr. Keiichiro Matoba contributes an elegant article particularly focusing on the promising potential of Rho-associated, coiled-coil-containing protein kinase (ROCK) for the treatment of diabetic nephropathy. ROCK signaling is known to exaggerate in the diabetic kidney. Of note, ROCK1 blunts AMPK signaling, thereby hampering mitochondrial function, while ROCK2 attenuates PPARα signaling, resulting in the decrease in fatty acid oxidation. Collectively, his work does shed light on the novel approach toward the diabetic nephropathy via kidney-specific inhibition of ROCK signaling.

  • Volume 70 (2023) Issue 7 Pages 655-662
    The impact of testosterone in men’s health Read more
    Editor's pick

    Age-related testosterone decline, also known as late-onset hypogonadism (LOH), is tightly linked with a wide variety of aging-related pathophysiology including sarcopenia, coronary arterial disease, arteriosclerosis, obesity disease, type 2 diabetes mellitus, mental health disorders and cognitive impairment. In this issue, Professor Hisamitsu Ide timely contributes an insightful and well-organized review article on testosterone with a specific view point of clinical and molecular endocrinology, underscoring the huge impact of testosterone on maintenance of male health in the super-aging society.

  • Volume 70 (2023) Issue 6 Pages 559-565
    Paraneoplastic autoimmune hypophysitis: a novel form of paraneoplastic endocrine syndrome Read more
    Editor's pick

    Immune-related adverse effects observed in a variety of endocrine organs caused by immune checkpoint inhibitors (ICIs) afresh underscore the impact of onco-immuno-endocrinology on the pathophysiology and pathogenesis of paraneoplastic endocrine syndrome. In this issue, Professor Yutaka Takahashi contributes a terrific, well-organized article on the recent research progress particularly in the category of paraneoplastic autoimmune hypophysitis including anti-PIT-1 hypophysitis, isolated ACTH deficiency and ICI-related hypophysitis.

  • Volume 70 (2023) Issue 5 Pages 465-472
    Glucose and lipid metabolisms in human endometrial stromal cells during decidualization Read more
    Editor's pick

    Reproductive endocrinology provides us with a lot of tips in a various area of medical science. In this issue, Dr. Tamura and colleague contribute an insightful review article focusing on glucose and lipid metabolism in human endometrial stromal cells during the course of decidualization. To effectively supply energy for embryo, human endometrial stromal cells aggressively ingest fuel via GLUT1 and VLDL receptor under the transcriptional control and epigenetic modification involved in C/EBP beta, p300 and WT1. Such a fashion would be reminiscent, at least in part, of fuel metabolism commonly seen in cancer cells. It is also anticipated that energy metabolism-based unique approach in this article opens a fresh avenue for cutting edge medicine and therapeutics on incomplete implantation or infertility.

  • Volume 70 (2023) Issue 4 Pages 343-358
    Neuroendocrine regulation of reproduction by GnRH neurons: multidisciplinary studies using a small fish brain model Read more
    Editor's pick

    As well known, comparative endocrinology has long provided deep insight into pathophysiology and molecular basis of a variety of human endocrinologic diseases. In this issue, by use of a small fish model, Dr. Yoshitaka Oka contributes an extensive, well-organized article on the recent research progress in neuroendocrine regulation of reproduction by GnRH neurons, providing us with an invaluable perspective for cutting-edge area of reproductive endocrinology in humans.

  • Volume 70 (2023) Issue 3 Pages 295-304
    Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency Read more
    Editor's pick

    It is well recognized that a line of symptoms of neurohypophyseal diabetes insipidus (NDI), also known as arginine vasopressin (AVP) deficiency, are masked under the condition of adrenal insufficiency. However, molecular mechanisms whereby polyuria manifests after the administration of glucocorticoids in patients with masked NDI have not been fully elucidated. Kurimoto J and colleague elegantly solved this long-lasting enigma via comprehensive analyses including patients with masked NDI as well as murine model of familial NDI. They provide a convincing proof that mineralcorticoids directly attenuate the expression of aquaporin-2 in the apical membrane of collecting duct, thereby leading to the increase in urine volume in patients with NDI.

  • Volume 70 (2023) Issue 1 Pages 69-76
    Clinical characteristics and efficacy of pioglitazone in a Japanese patient with familial partial lipodystrophy due to peroxisome proliferator-activated receptor γ gene mutation Read more
    Editor's pick

    To date, familial partial lipodystrophy (FPLD) has been known to consist of seven types, and FPLD type 3 is a rare autosomal dominant genetic disorder caused by mutations of peroxisome proliferator-activated receptor γ gene. In this issue, Dr. Iizaka and colleague report the first pedigree of FPLD 3 in Japanese exemplifying prolonged insulin resistant diabetes mellitus, liver steatosis and hypertriglyceridemia with a relatively low degree of BMI and percentage of body fat. For all endocrinologists, attention should be paid to avoid overlooking lipodystrophy syndromes.

  • Volume 69 (2022) Issue 11 Pages 1285-1293
    Thyrotropin receptor antagonists and inverse agonists, and their potential application to thyroid diseases Read more
    Editor's pick

    Molecular research on agonists / antagonists / inverse agonists in a variety of G-protein coupled receptors (GPCRs) has long attracted robust attention of endocrinologists. In this issue, Dr. Nagayama and Dr. Nishihara contributes an encyclopedic, well-organized article on the update of antagonists / inverse agonists research around the thyrotropin receptor (TSHR), providing us with promising therapeutic potential for Graves’ hyperthyroidism, non-autoimmune hyperthyroidism, thyroid cancer and resistance to thyroid hormone.

  • Volume 69 (2022) Issue 10 Pages 1159-1172
    Therapeutic role of mesenchymal stem cells (MSCs) in diabetic kidney disease (DKD) Read more
    Editor's pick

    It has long been recognized that uncontrolled high blood pressure, dysmetabolism of glucose and lipids, and sustained inflammation and fibrosis are involved in the pathophysiology and progression of diabetic kidney disease (DKD) in an extremely complexed manner. It is therefore exactly a herculean issue to accurately identify patients with higher risks than we would imagine for end-stage renal diseases (ESRDs). In the October issue, Dr. Xu Ning and colleague provide an attractive review article focusing on potentials of mesenchymal stem cells (MSCs) for the treatment of such an intractable medical condition.

  • Volume 69 (2022) Issue 9 Pages 1053-1060
    Effects of tubastatin A on adrenocorticotropic hormone synthesis and proliferation of AtT-20 corticotroph tumor cells Read more
    Editor's pick

    Epigenome-based drugs such as inhibitors against DNA methyltransferases (DNMTs) and histone deacetylase (HDACs) have long been employed for the treatment of a variety of malignancy and pre-cancer status. In this issue, Dr. Rie Hagiwara and colleague provide a convincing data set of in vitro experiments demonstrating a selective HDAC6 inhibitor, tubastatin A substantially suppresses the growth of as well as the ACTH secretion from a murine corticotroph cell line, AtT-20. The present study may open a fresh avenue for brand-new therapeutics in humans on pituitary neuroendocrine tumors including Cushing’s disease.

  • Volume 69 (2022) Issue 8 Pages 881-896
    Advances in understanding of phosphate homeostasis and related disorders Read more
    Editor's pick

    Science and clinics on phosphate homeostasis are no doubt an authentic, royal road to endocrinology. As most of readers of Endocrine Journal well recognize, basic scientists and endocrinologists in Japan have made a huge contribution to the molecular medicine on fibroblast growth factor 23 (FGF 23) in this academic field. To STATE-OF-THE-ART REVIEW IN ENDOCRINOLOGY in this issue, Dr. Michigami contributes an extensive, well-organized article on the recent research progress in phosphate homeostasis and related disorders with a particular emphasis on FGF 23, providing us with an invaluable perspective for cutting-edge area of bone-mineral endocrinology.

  • Volume 69 (2022) Issue 7 Pages 739-748
    New perspectives on obesity-induced adipose tissue fibrosis and related clinical manifestations Read more
    Editor's pick

    Dynamic remodeling of adipose tissue plays a critical role in the pathophysiology of obesity disease. In this article, Dr. Yutaka Hasegawa elegantly updates the research on the molecular mechanism whereby adipocytes interact with non-adipocytes during the course of adipose dysfunction and fibrosis in obesity. This review does provide us with invaluable perspective for endocrinology-based obesity science.