抄録
Biopsied canine liver tissues were investigated histochemically by electron microscopy to demonstrate copper localization. The samples were fixed and stained with the modified sulfide-silver method with a combination of iron and zinc removal. Using this method, the hepatic copper, even at a low concentration of 30 μg/g dry weight, was detectable. Copper was found in the hepatocyte lysosomes or in the cytoplasm as electron-dense granules.
