Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Skeletal Malformations Caused by the Dh (Dominant hemimelia) Gene in Mice
Jun-ichi SUTOTeruhiko WAKAYAMAKenkichi IMAMURASaori GOTOKatsuhiro FUKUTA
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1996 Volume 45 Issue 1 Pages 95-98


Morphological characterization of the skeletal malformations caused by the Dh gene was carried out. Skeletal preparations from newborn mice of Dh/Dh, Dh/+ and +/+ genotypes, and adult Dh/+ mice were examined. The Dh gene induced skeletal deformities at the axial regions from the thorax to the tail. Attachment of the ribs to the sternum was sometimes irregular, and normal segmentation of the sternum was also disrupted. Abnormal fusion of the ventral part of the rib was observed in some cases. Lumbar vertebrae were fewer in number and abnormal in shape. Although it was rare, a curled tail was also observed due to distortion of the caudal vertebrae.

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© 1996 Japanese Association for Laboratory Animal Science
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