High Lethality of F₁ (D h/+) Male Mice from the Cross between DDD Female and DH (Dh/+) Male

Abstract

The present study demonstrates the incidence of high lethality of F₁ (Dh/+) male mice, the offspring of DDD females and inbred DH (Dh/+) males. Among the newborn pups, the numbers of F₁ (Dh/+) males are comparable to those of mice having other genotypes (+/+ male, Dh/+ female and +/+ female), but many F₁ (Dh/+) males died before weaning. On the other hand, among the F₁ mice from the cross between DH (Dh/+) females and DDD males, there are no biased numbers of Dh genotype pups. These results suggest the existence of defects in the interaction between the male derived Dh gene and the genetic traits of the DDD female.