Replication of Murine Coronaviruses in Mouse Embryonic Stem Cell Lines in vitro

Shigeru KYUWA

doi:10.1538/expanim.46.311

Experimental Animals

Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124

Note

Replication of Murine Coronaviruses in Mouse Embryonic Stem Cell Lines in vitro

Shigeru KYUWA

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Keywords: embryonic stem cells, mouse hepatitis virus, viral replication

JOURNAL FREE ACCESS

1997 Volume 46 Issue 4 Pages 311-313

DOI https://doi.org/10.1538/expanim.46.311

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Abstract

Replication of murine coronaviruses in eight mouse embryonic stem (ES) cell lines of several genetic backgrounds was examined. Both mouse hepatitis virus (MHV) type 2 and MHV, strain A59 replicated well with no or minimal cytopathic effect in all the ES cell lines tested. The results suggest the possibility that MHV-infected ES cells may disseminate MHV in mouse colonies due to embryo manipulation.

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