Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse β Cells

Haruo HASHIMOTO; Naoki MORITANI; Misao TERADA; Pudcharaporn KROMKHUN; Wirasak FUNGFUAUG; Tomoaki NAKADA; Makoto YOKOSUKA; Toru R. SAITO

doi:10.1538/expanim.59.515

Note

Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse β Cells

Haruo HASHIMOTO, Naoki MORITANI, Misao TERADA, Pudcharaporn KROMKHUN, Wirasak FUNGFUAUG, Tomoaki NAKADA, Makoto YOKOSUKA, Toru R. SAITO

著者情報

キーワード: bioartificial endocrine pancreas, diabetic rats, streptozotocin

ジャーナルフリー

2010 年 59 巻 4 号 p. 515-519

DOI https://doi.org/10.1538/expanim.59.515

詳細

抄録

We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse β cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380–450 mg/dl induced by streptozotocin to 140–230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.

責任著者(Corresponding author)

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