Improvement of Non-Alcoholic Fatty Liver Disease by a Nutritional Instruction for Six Months

Abstract

The nutritional instruction recommending calorie restriction and fish intake was given to 16 male subjects with non-alcoholic fatty liver disease (NAFLD) for 6months. NAFLD score reduction based on the ultrasonographic pattern was observed in 10 of 16 subjects (improved group). In addition, significant reduction in body weight, body mass index, ALT and HOMA-IR was observed in the improved group. Although the reduction in energy intake was observed in both improved and non-improved groups, the significant increases in the intake of n-3 polyunsaturated fatty acid (n-3PUFA) and fish and the plasma levels of n-3PUFA and docosahexaenoic acid were only observed in the improved group. These results suggest that the fish intake with the reduction in energy intake is effective for the improvement of NAFLD.