Abstract
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) are present in the somatic
stem cell pool of the bone marrow. While MSCs differentiate primarily into osteoblasts,
adipocytes and chondrocytes, HSCs differentiate primarily into hematopoietic cells and osteoclasts.
Since somatic stem cells are present in a niche isolated from the external environment,
they were conventionally considered to be less susceptible to the influence of changes in the
external environment caused by aging. However, it has become clear from recent studies that
changes in the bone marrow environment due to aging alter the properties of somatic stem
cells in the bone marrow, thereby resulting in a decrease in bone density. In this review, we
introduced the changes in the properties of somatic stem cells due to lifestyle diseases and
dietary habits, in addition to aging.
