Effect of oral administration of the porcine liver hydrolysate on blood lipid levels

Abstract

 In the present study, the effects of porcine liver hydrolysate (PLH) on in vivo plasma lipid levels and in vitro lipid metabolism, and were investigated. The effects of PLH on serum cholesterol levels were investigated by feeding high fat diet (HFD) to mice. The levels of total and LDL cholesterol were significantly lower than in the HFD group by feeding PLH. Lipid metabolisms related gene expressions in vitro were analysed by RT-PCR. PLH decreased low-density lipoprotein receptor (LDLR) expression. These evidences indicate PLH has serum cholesterol-lowering effects, owing to an increase in LDLR expression in hepatocytes.