セルロース透析膜の生体適合性と膜に含まれる水分子の¹H-NMR緩和

抄録

Spin-lattice relaxation time, T₁ of water molecules (H₂O/Cellulose=0.08, 1.1, 2.0 (g/g)) was estimated by ¹H-NMR technique for the five regenerated cellulose membranes with different water contents, and related to a biocompatibility and a structure of the membrane. In all water contents investigated here, two T₁ components (T_{1, l}>T_{1, s}) were observed. A degree of complement activation, A_c which was estimated as an index of biocompatibility showed good correlation with porosity, P_r of the dried sample, not with an aggregation structure of cellulose chains (e. g. crystallinity), suggesting that the A_c was mainly influenced by a surface area of the membrane. In addition, it was found that the sample having the larger P_r or the higher A_c tends to have the shorter T_{1, l} value, especially in the swollen state. These results lead to a conclusion that T_{1, l} value estimated for the swollen sample can be regarded as an index parameter for a biocompatibility, because this value reflects a surface area of the swollen cellulose membrane.