Spin-lattice relaxation time,
T1 of water molecules (H
2O/Cellulose=0.08, 1.1, 2.0 (g/g)) was estimated by
1H-NMR technique for the five regenerated cellulose membranes with different water contents, and related to a biocompatibility and a structure of the membrane. In all water contents investigated here, two
T1 components (
T1, l>
T1, s) were observed. A degree of complement activation,
Ac which was estimated as an index of biocompatibility showed good correlation with porosity,
Pr of the dried sample, not with an aggregation structure of cellulose chains (e. g. crystallinity), suggesting that the
Ac was mainly influenced by a surface area of the membrane. In addition, it was found that the sample having the larger
Pr or the higher
Ac tends to have the shorter
T1, l value, especially in the swollen state. These results lead to a conclusion that
T1, l value estimated for the swollen sample can be regarded as an index parameter for a biocompatibility, because this value reflects a surface area of the swollen cellulose membrane.
抄録全体を表示