抄録
Investigating the influence of various temperatures, i. e. 5°, 10°, 15°, 20°, 25°, 30° and 35° C, on the paralytic action of salicylamide, benzamide, ethylalcohol, acetone, chloralhydrate and ethylurethane on the sciatic nerves of frogs, the author obtained the following results :
The higher the temperatures applied, the sooner the effects of ethylalcohol, chloralhydrate, ethylurethane, acetone and benzamide are brought out. But it would seem that acetone paralyses the nerve sooner at 5° than at 10° and benzamide abolishes the conductivity of the nerve-fibres in almost the same time either at 5° or at 10°. Up to 25° the paralytic action of salicylamide seems to develop more and more slowly, while above 25° it becomes more and more rapid.
The minimum paralytic concentrations of salicylamide, benzamide, ethylalcohol, chloralhydrate and acetone on nerve-fibres are changed by temperature in a direction contrary to the change of the partition-coefficients between oil and water, as proved by H. H. Meyer on tadpoles. But the minimum paralytic concentration and the partition coefficient almost cannot be in inverse proportion to each other. The author would, therefore, believe that the change of the minimum paralytic concentration of a narcotic caused by temperature, is due not only to the influence of temperature on its partition coefficient, as Meyer has suggested, but also to the change of the sensibility of the nerve-fibres to it.
